
Set in the Meiji era, two young women who graduate from the same nursing school forge an unbreakable bond as they navigate the hardships of early modern medicine, working tirelessly alongside doctors while fighting to prove themselves in a changing Japan.

The First Investigative Division is the star unit of the Tokyo Metropolitan Police Department. Jun'ichi Ōiwa, the head of the division, leads around 400 elite detectives. He has an extremely heavy responsibility: attends initial investigations at the scenes of all brutal crimes that occur within the metropolis, decides on the course of action of the investigations at the same time as he directs many investigation task forces and gets into investigations himself at the critical phase. However, Ōiwa is definitely not a superman. Amid his suffering, Ōiwa overcomes this grave responsibility and is quite simply a "life-size hero" and "ideal boss" to his subordinates.

Ryōsuke Sagara is an ordinary salaryman and he works for a mid-size shipping company. He is a good-natured person. His family consists of his wife Maho, high school student daughter and elementary school student son. Maho works part-time at a supermarket. They are a happy family, but Maho and their two children suddenly disappear. There are no clues about their disappearance. Ryōsuke gets the attention of the media and public. He tries to find the truth behind his family's disappearance with the help of his subordinate Mizuho Ninomiya at work.

20-year-old rookie police officer Kawai Mai works hard at a police box and feels both physically and mentally drained. She has never felt appreciated even though she supposedly works for the sake of the area’s residents. In addition, she does not find working at a police box rewarding. Mai is about to hand in her resignation when she meets 30-year-old Fuji Seiko, the former ace detective of the Criminal Investigations Division. Seiko is said to have been forced to transfer to the police box for harassing a subordinate at work but … … This encounter between Mai and Seiko will significantly change their lives as they are suddenly paired up. This odd pair struggle to help and support each other in cases, routine duties and romance?! And Seiko’s true reason for coming to the police box is revealed.

Seishiro Tokai (Kazunari Ninomiya) works as a surgeon at a university hospital. He possesses excellent technique with suture and carries a surgery success rate of 100%. Due to his arrogant attitude and personality, he comes into conflict with those around him. A new doctor tries to introduce the latest medical device for surgery, which doesn't need a surgeon's hand. Seishiro Tokai is skeptical of the device. He faces the university hospital administration and reveals corruption and hidden past behind the medical device.

Sato, a young woman from a modest family, marries Kenta, a young man from a well-to-do and respected family. She settles in the family's home, where she meets the father, Keiichi, a strict man, Mihoko, the unfriendly sister-in-law and Akito, the elder brother. Although not everyone sees the union of Kenta and Sato in a very good light, the father seems to have great plans for our heroine.

A popular English teacher, Mizuguchi Risako has been kidnapped three days before the high school's graduation ceremony. Four high school seniors received a mysterious challenge letter, asking them to solve the mystery of the kidnapping case within 72 hours. The four students are Kurokawa Yoshiki, his childhood friend Takahata Ayane, sports all-rounder Ogita Junpei, and school's beauty contest winner Komatsu Mio. The four students were wondering why they're the only ones who received the letter, but later gradually found out the "other face" of Mizuguchi which she has been hiding.

Parliamentary secretary Toru Washizu (Tsuyoshi Kusanagi) has devoted 20 years of his life to Kosuke Inukai, a member of parliament and cabinet minister. Toru works behind the scenes as Inukai's "shadow," deftly handling the petitions of Inukai's supporters and crushing any hint of scandal. Cool and collected, Toru rarely betrays emotion and would humble himself to anyone to get what Inukai needs. But then a shocking event changes everything. Toru's only son, Taiki, is gravely injured in an accident that leaves him close to death. Toru is stricken with worry and fear for his son, but Inukai orders him to conduct a cover-up. Feeling betrayed, Toru, who once would have done anything for Inukai, begins to question everything.

Nao spent her formative years living at Kogetsuan, a well-established Japanese confectionery shop, where her single mother worked as a pastry chef. She is the same age as Tsubaki, heir to the store, and they become each other's first love. One morning, Tsubaki's father and head of Kogetsuan is stabbed and found covered in blood. Nao's mother is arrested based on the six-year-old Tsubaki's testimony and the little girl is kicked out of the shop. Nao's mother died while the investigation was going on, preventing the truth to emerge. Fifteen years later, the case is still shrouded in mystery. Is she really the culprit?

The story is set in a big hospital which is infiltrated and taken over by an armed group wearing devil masks. Musashi Saburo a police officer on leave of absence has to save the hostages within a set time limit.

Ambitious banker Asuka Takanashi dreams of marriage and life as a housewife, but when she falls for popular newscaster Ryu Nanami—who vows never to wed—their romance turns into a clash of ideals, testing whether love can overcome their opposing views on marriage.

Sarukawa Kenta, a marketer for a mid-range drinks company based in Osaka, is transferred to the Tokyo office for a good job. But in the new place, all difficult clients were thrown off on him, and his colleagues are in no hurry to make friends with him. Influenced by his new boss Tanioka Kazuhiko, who loves very spicy food, Sarukawa also decides to enter the spicy kitchen.

Keito is a reporter for a weekly magazine. The magazine covers everything from corruption by politicians to entertainers' scandals. She watches out for the next big scoop. Keito is also rich and enjoys her work, as well as her love life. One day, Keito's mother suddenly dies. Anna was a single mother who raised Keito alone. She worked as a movie critic. Right before her death, Anna mentioned something about Keito's father. The name she mentioned is that of a Hollywood star.

Upon learning their employer is transferring an unmarried person to Alaska, coworkers Rika and Takuya decide to tie the knot in order to dodge a bullet.

Haruno Shotaro and his girlfriend Mimori Arisa get into a car accident. The next moment, when he wakes up, he finds out that he is in the hospital and has a cast on his right foot and left hand. Soon, Haruno Shotaro thinks that something is really strange with the hospital. The hospital has weird patients and the doctors and nurses seem to be hiding something. A mysterious serial murder case also takes place outside the hospital. What is the connection between the hospital and the serial murder case? What is happening in the hospital?